The Phillies hurler will be making his first start against his former team at Rogers Centre since being traded in December 2009. He has since proven to be just as superb after switching uniforms.
The defending National League Cy Young Award winner is working on another stellar campaign, having already reached double-digits in victories and tallied five complete games.
"I feel like it's any other start," Halladay said this week. "It's been long enough for me where that's not really something that's in the forefront.
"I've been out of there for a while, I just feel like it's a regular road start. Obviously, it's the first time back, but I don't really anticipate anything different than any other road start."
It likely won't be just another home game for the Blue Jays' fans, who are expected to flock to the ballpark. If Friday was any indication, Halladay will be well received. He was given an extended ovation prior to the Phillies' 7-6 win in the opener, when he took the lineup card to home plate.
"I have a pretty good idea that our fans are going to give him a very warm reception," said Blue Jays shortstop John McDonald, who played several seasons with Halladay. "He did do some really great things here on the field and off the field. You would also hope that they'll cheer pretty strongly for us for nine innings and give him his just due."
Halladay, a first-round Draft pick by the Blue Jays in 1995, was 148-76 with a 3.43 ERA in 12 seasons with the Blue Jays. He was a six-time All-Star and the 2003 AL Cy Young Award winner with Toronto.
Saturday, he'll be up against a club that has not thrived against the National League recently. The Blue Jays are 7-9 this season against the NL and have won just 10 of their past 24 Interleague games since 2010.
At Rogers Centre, Toronto has won just eight of its past 20 against the NL since 2009. The Blue Jays have also lost nine of 12 at home overall.
Phillies: Victorino heating
Outfielder Shane Victorino, 3-for-4 with two runs and two RBIs in the series opener Friday, is batting .314 (33-for-105) with six doubles, four triples, three homers, 14 RBIs and 27 runs in 27 games since being activated from the disabled list on June 3.
He is 7-for-16 with a homer and five RBIs against the Blue Jays since last year.
With a victory Friday against the Blue Jays, the Phillies have strung together consecutive winning seasons in Interleague Play for just the second time in club history. Philadelphia, 10-8 last year, was 10-8 and 8-7 from 2002-03.
Blue Jays: Villanueva solid so far
Halladay may receive most of the attention on the mound Saturday, but his counterpart hasn't been too bad, either. Toronto right-hander Carlos Villanueva is coming off a solid start against the Cardinals in which he scattered five hits and two runs over six innings.
Villanueva (5-1, 3.15 ERA) has lost just once in his last 10 starts. He has a 1.26 ERA in 14 1/3 career innings against the Phillies.
The Blue Jays have hit a home run in nine straight games (15 total), setting a new season high.
Halladay beat the Blue Jays last year in Philadelphia, throwing seven shutout innings on June 25.
Toronto shortstop Yunel Escobar left Friday's game in the first inning after being hit by a pitch on the left hand.
The Phillies will play their third in a string of four consecutive day games on Saturday. They've split the first two and own a 19-7 mark in afternoon games this year.